Poirier, J. et al. We receive compensation from companies whose products and services we recommend. Etminan, M., Gill, S. & Samii, A. Moreover, if you keep on practicing these exercises over a long period of time, its going to bring some miraculous results for you. This site uses cookies to assist with navigation, analyse your use of our services, collect data for ads personalisation and provide content from third parties. June 15, 2021 Lipophilic statin use linked to increased risk of dementia by Society of Nuclear Medicine and Molecular Imaging Significant metabolic decline in the posterior cingulate cortex. Rockwood, K. et al. However, by engaging yourself in laughter, you reduce the levels of your stress and improve the capabilities of your memory. Arch Neurol 59, 378384 (2002). drugs and one of the most common afflictions of the aging brain," noted aRRs) in each included study. Lipophilic Statin Use Linked to Increased Risk of Dementia Kandiah, N. & Feldman, H. H. Therapeutic potential of statins in Alzheimers disease. As far as foods are concerned, you need to include fruits and green vegetables in your daily diet that supply the needed antioxidants to protect the brain cells from getting damaged. Taken together, statins could attenuate the cognitive decline via, at least in partial, decreasing anti-inflammatory action, attenuate formation of beta-amyloid (-amyloid) and neurofibrillary by lowering cholesterol levels, and pleiotropic effects. International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM). group. the Science X network is one of the largest online communities for science-minded people. After practicing it for a particular time, it becomes very exciting for anyone to remember things in the form of rhymes. We conducted the meta-analyses with random-effects models due to the anticipated heterogeneity across studies. Therefore, the current systematic review and meta-analysis aims to reappraise available evidence from prospective studies, which investigated whether statins use could diminish incident all-caused dementia, AD, VaD, and MCI. Copyright 2001-2022 MedLink, LLC. After a long day of work, our body needs sound sleep at night and this is also important to stabilize the functionality of the brain. My heart froze as I watched this video explaining how these brilliant scientists managed to revoke Alzheimer, dementia and 3 other types of brain diseases in 100% of cases. Future intervention studies are needed to better study the differential effects of hydrophilic and lipophilic statins on preventing incidence of dementia or otherwise as novel neuroprotector agents for MCI and AD. There are certain exercises that help in evolving the functionality of the brain and the power of memory. In patients with mild cognitive impairment, taking lipophilic statins A systematic review and meta-analysis of randomized controlled trials. Subgroup analyses were performed when data from at least three datasets. For each meta-analysis, we considered the risk measure of each study which was most fully adjusted for potential confounders. Correspondence to Several limitations should be addressed. Lipophilic Statin Use Linked to Increased Risk of Dementia June 14, 2021 Reston, VA (Embargoed until 7:30 p.m. EDT, Monday, June 14, 2021) In patients with mild cognitive impairment, taking lipophilic statins more than doubles their risk of developing dementia compared to those who do not take statins. Do hydrophilic statins cause dementia - slsi.lk and cognition in the molecular and medical pharmacology student research All rights reserved. Che-Sheng Chu and Ping-Tao Tseng contributed equally to this work. Neurology 71, 344350, https://doi.org/10.1212/01.wnl.0000319647.15752.7b (2008). memory, attention, language, and problem solving)2. However, this is beyond the scope of current meta-analysis. Li, G. et al. Alzheimers & Dementia 13, 736737 (2017). You are using a browser version with limited support for CSS. MathSciNet In a nutshell, laughter brings down the cortisol stress hormone. Thus, clearly more research is required to consider if statins may confer a protective effect over future VaD. Therefore, it is possible that statins might not offer an independent preventative benefit for VaD. Second, the degree of exposure (i.e. Lancet 361, 11491158, https://doi.org/10.1016/S0140-6736(03)12948-0 (2003). Different types of statins are available based on a patient's health needs, including hydrophilic statins that focus on the liver and lipophilic statins that are distributed to tissues throughout the body. "Findings from these scans could be used to inform Rodriguez, E. G., Dodge, H. H., Birzescu, M. A., Stoehr, G. P. & Ganguli, M. Use of lipid-lowering drugs in older adults with and without dementia: a community-based epidemiological study. Lipid lowering agents, cognitive decline, and dementia: the three-city study. Twenty-five studies met eligibility criteria. Refined sugar leads to difficulties in forming new memories, depression, and a reduction in the brain functions. Third, we only included peer-reviewed articles published in English language and thus it is possible that we might have missed some non-English studies. Statins and Dementia: Are Some Folks More Prone to Harm? In addition, apoE4 allele is a major genetic risk factor for both all-caused dementia and AD70. of lipophilic statin users also showed a substantial decline in The question here is does age have anything to do with this process. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in There are many other similar devices that you can be applied for this purpose but, the best thing you can do is to innovate some own techniques to improve memory. Do statins impair cognition? Lipophilic vs Hydrophilic Statins Memory Loss Overview Lipophilic vs Hydrophilic Statins Memory Loss While memory lapses are inevitable, luckily, most cases of memory loss are treatable. Impact of statin dosing intensity on transaminase and creatine kinase. https://doi.org/10.1212/WNL.0000000000004818 (2017). Over time, PET imaging Subgroup analyses stratified by pharmacokinetic properties of statins (hydrophilic vs lipophilic), as previous studies, showed inconsistent results regarding the protective effect of hydrophilic and lipophilic statins on cognition10,38. Low dose hydrophilic statins are the preferred agents for - PubMed It is said that to achieve something you never had, you must do something you never did. Use of Statins and Risk of Dementia in Heart Failure: A Retrospective Cohort Study. Curr Alzheimer Res 5, 416421 (2008). Neuroepidemiology 23, 9498, https://doi.org/10.1159/000073981 (2004). Pharmacotherapy 23, 726730 (2003). Finally, the effects of confounders may limit inferences from observational studies30, and hence may vary depending on both the specific population being examined and potential confounding variables that are controlled for in multivariable analysis. PRISMA flowchart of study selection for the current systematic review and meta-analysis. Besides, these studies did not account for important factors (such as plasma lipids or apolipoprotein E genotype)8,22,23, which might influence the results. Atherosclerosis is considered to be responsible for diffuse periventricular white matter abnormalities, which are one of major pathophysiological mechanisms of VaD55. Thus, patients on lipophilic statins had statistically lower BMD than females on hydrophilic statins. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes TrialLipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. While hydrophilic statins focus on the liver, lipophilic statins are distributed to tissues throughout the body. J Neurol Sci 283, 230234, https://doi.org/10.1016/j.jns.2009.02.352 (2009). Science X Daily and the Weekly Email Newsletter are free features that allow you to receive your favorite sci-tech news updates in your email inbox, Medical Xpress 2011 - 2022 powered by Science X Network. https://doi.org/10.1093/gerona/glx234 (2017). Article Solomon, A., Soininen, H., Laatikainen, T., Tuomilehto, J. Finally, 25 articles met inclusion criteria. The protective effects of statins on preventing the onset of dementia which can emerge as a function of their pharmacokinetic properties remains under debate, with some studies favoring lipophilic statins38 but other showing no difference between hydrophilic and lipophilic statins10. For better remembrance, we always try to create an association between pieces of information. Do statins reduce risk of incident dementia and Alzheimer disease? Internet Explorer). Two investigators (CSC and PTT) have independently performed database searching, study selection, data extraction, and the rating of the methodological quality of included studies. Our subgroup analyses show that significant reduced risks of all-caused dementia and marginal significances of lower risk of AD were found for hydrophilic statins. Across 6 studies9,16,36,42,45,48, participants who were using statins were significantly less likely to develop MCI compared with those who did not receive statins (aRR=0.737, 95% CI=0.5560.976, p=0.033). By submitting a comment you agree to abide by our Terms and Community Guidelines. This is basically a recipe for boosting the capacity of your memory. This becomes very important when it comes to remembering some things. We used the Newcastle-Ottawa Scale (NOS) to rate the methodological quality of included studies82. Stephen Liu and Daniel Silverman, University of California, Los Angeles, Unsurprisingly, the prevention of cognitive decline and dementia is a worldwide public health issue4. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Congenital Heart Disease and Pediatric Cardiology, Invasive Cardiovascular Angiography and Intervention, Pulmonary Hypertension and Venous Thromboembolism, ACC Anywhere The ACC.22 Meeting on Demand Program, CardioSource Plus for Institutions and Practices, Annual Scientific Session and Related Events, ACC Quality Improvement for Institutions Program, National Cardiovascular Data Registry (NCDR). There are several ways in which you can exercise your brain to improve it. Rhymes Lipophilic vs Hydrophilic Statins Memory Loss. Use this form if you have come across a typo, inaccuracy or would like to send an edit request for the content on this page. However, a poor remembrance habit Brauner, D. J., Muir, J. C. & Sachs, G. A. Lipophilic statins were associated with reduced risk of AD (aRR=0.639; CI=0.4490.908; p=0.013) but not all-caused dementia (aRR=0.738; CI=0.4751.146; p=0.176). & Brooks, C. Measurements of Daily Energy Intake and Total Energy Expenditure in People with Dementia in Care Homes: The Use of Wearable Technology. Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Center for Geriatric and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Department of Psychiatry, Tsyr-Huey Mental Hospital, Kaohsiung Jen-Ais Home, Kaohsiung, Taiwan, WinShine Clinics in Specialty of Psychiatry, Kaohsiung, Taiwan, Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London, UK, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), Kings College London, De Crespigny Park, London, UK, Faculty of Health, Social Care and Education, Anglia Ruskin University, Chelmsford, UK, Department of Psychiatry, Tri-Service General Hospital; School of Medicine, National Defense Medical Center, Taipei, Taiwan, Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, Department of Psychiatry, Tainan Hospital, Ministry of Health and Welfare, Tainan, Taiwan, Department of Addiction Science, Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan, Graduate institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Department of Adult Psychiatry, Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan, Prospect clinic for otorhinolaryngology & neurology, Kaohsiung, Taiwan, National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy, Department of Psychiatry, University of Toronto, Toronto, ON, Canada, Centre for Addiction & Mental Health (CAMH), Toronto, ON, Canada, IMPACT Strategic Research Centre, School of Medicine, and Barwon Health, Deakin University, Geelong, Australia, Laboratory of Calcium Binding Proteins in the Central Nervous System, Department of Biochemistry, Federal University of Rio Grande do Sul, Porto, Alegre, Brazil, Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, Institute for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, You can also search for this author in Decline in the question here is does age have anything to do with this.! 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