Usually, government's categorizes medicines that can be addictive as controlled substances. Carbenoxolone: As carbenoxolone may cause sodium retention and thus decrease the effectiveness of spironolactone, concurrent use of the two agents should be avoided. Because spironolactone has been found to be tumorigenic in rats, a decision should be made whether to discontinue the drug, taking into account the importance of the drug to the mother. In the placebo-controlled hypertension studies whose design allowed side-effect rates to be attributed to dose, excessive urination was reported by 1% of patients receiving placebo, 4% of those treated with 5 mg of daily torsemide, and 15% of those treated with 10 mg. Soft Skills: The 11 Essential Career Soft Skills, Acceptance and Commitment (AC) Coaching: Sexual Relationship Coaching for Committed Couples, Maharashtra Knowledge Corporation Limited, Destroy Negative Emotions with the Power of Self-Regulation, Echocardiography for the Non-Cardiologist, Fluid retention in liver or kidney disease, Be careful in case of electrolyte imbalance, diabetes mellitus and hyperuricaemia, Check your blood pressure one week after starting the drug, Consult a doctor if you have hepatic impairment, diabetes mellitus, Consult your doctor if you are taking corticosteroids or blood pressure or diabetes medicines, Continue taking the medicine even if you start feeling well. Of the side effects listed in the table, only “excessive urination” occurred significantly more frequently in patients treated with torsemide than in patients treated with placebo. It may be necessary to reduce the maintenance and digitalization doses when DYTOR PLUS is administered, and the patient should be carefully monitored to avoid over- or under-digitalization. It is critical to monitor and manage serum potassium in patients with severe heart failure receiving spironolactone. Persistent hyperkalemia may require dialysis. In patients with hepatic disease with cirrhosis and ascites, diuresis with any diuretic is best initiated in the hospital. Single doses of torsemide caused healthy volunteers to increase their urinary excretion of magnesium, but serum magnesium levels were slightly increased in 4- to 6-week hypertension trials. Serum and urine electrolyte determinations are particularly important when the patient is vomiting excessively or receiving parenteral fluids. Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Skin/allergy: In isolated cases, there may be allergic reactions, such as pruritis and photosensitivity. This may be minimized by lowering the starting dose of the ACE inhibitor and/or reducing or stopping temporarily the dose of torsemide. Trademarks & Tradenames used herein are the property of their respective holders. When torsemide is used simultaneously with cardiac glycosides, a potassium and/or magnesium deficiency may increase sensitivity of the cardiac muscle to such drugs. Absorption is essentially unaffected by renal or hepatic dysfunction. This 10 CEU Coach Training Course integrates Acceptance and Commitment (AC) Coaching principles and practices into sexual relationship coaching. The daily doses of torsemide used in these trials ranged from 1.25 mg to 20 mg, with most patients receiving 5 mg to 10 mg; the duration of treatment ranged from 1 to 52 days, with a median of 41 days.

Retrieved June 13, 2020, from https://www.tabletwise.com/dytor-plus-10-tablet, "Dytor Plus 10 Tablet - Uses, Side-effects, Reviews, and Precautions - Cipla - TabletWise". There is no human experience with overdoses of torsemide but the signs and symptoms of torsemide overdosage can be anticipated to be those of excessive pharmacologic effect: dehydration, hypovolemia, hypotension, hyponatremia, hypokalemia, hypochloremic alkalosis, and hemoconcentration. However, clinical experience indicates that dosage adjustment of either agent is not required. Diuretic activity thus correlates better with the rate of drug excretion in the urine than with the concentration in the blood. Dytor Plus Tablet is used to treat edema, heart failure, swelling of lungs etc. Trademarks & Tradenames used herein are the property of their respective holders. Some of these calculi have been dissolved, and hypercalciuria has been reported to have decreased, when chlorothiazide has been coadministered along with the loop diuretic. Hyperkalemia may be fatal. Metabolism: hyperkalemia, electrolyte disturbances. Further, in severe cases of edema, where a greater amount of loop diuretic is desired, the patient could be shifted to four tablets of DYTOR PLUS 20. Concomitant administration of spironolactone with the following drugs or potassium sources may lead to severe hyperkalemia: Spironolactone should not be administered concurrently with other potassium-sparing diuretics. The reported side effects of torsemide were generally transient, and there was no relationship between side effects and age, sex, race, or duration of therapy. Hepatic function abnormal. Possible interactions between torsemide and NSAIDs (including aspirin) have not been studied, however, coadministration of these agents with another loop diuretic (furosemide) has occasionally been associated with renal dysfunction. Treatment of overdosage should consist of fluid and electrolyte replacement. By competing with aldosterone for receptor sites, spironolactone provides effective therapy for the edema and ascites in those conditions. Drug Composition Information. What other medicines does Dytor Plus LS Tablet interact with? Please follow your, TabletWise.com website users have most commonly reported using Dytor Plus 10 Tablet after food. However, this may not be reflective of how you should use this medicine. Consequently, DYTOR PLUS is contraindicated in pregnancy. What other medicines does Dytor Plus 10 Tablet interact with? Spironolactone is effective in lowering the systolic and diastolic blood pressure in patients with primary hyperaldosteronism. Induce vomiting or evacuate the stomach by lavage. Gynecomastia may develop in association with the use of spironolactone. Dytor Plus has Spironolactone and Torasemide which helps remove extra water from … There are no adequate and well-controlled studies with spironolactone in pregnant women. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently. In humans the potencies of TMS and 7-α-thiospirolactone in reversing the effects of the synthetic mineralocorticoid, fludrocortisone, on urinary electrolyte composition were 0.33 and 0.26, respectively, relative to spironolactone. If any of these occur, torsemide should be discontinued until the situation is corrected; torsemide may be restarted at a lower dose. Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Periodic determination of serum electrolytes to detect possible electrolyte imbalance should be done at appropriate intervals, particularly in the elderly and those with significant renal or hepatic impairments. The development of gynecomastia appears to be related to both dosage level and duration of therapy and is normally reversible whenever DYTOR PLUS is discontinued.



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